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Book Details:

Author: James R. Empfield
Date: 23 Aug 2016
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Original Languages: English
Book Format: Paperback::162 pages
ISBN10: 3662505673
ISBN13: 9783662505670
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Filename: reducing-drug-attrition.pdf
Dimension: 155x 235x 9.65mm::2,818g
Download Link: Reducing Drug Attrition

Reducing attrition in drug discovery: The role of biomarkers. This suggests that particular focus needs to be paid to validating these targets for drug discovery purposes as many experimental drugs that are designed to modulate the activity of a specific protein often fail to exhibit efficacy during clinical trials. Reducing Drug Attrition ISBN 9783662439135 Empfield, James R. (EDT)/ Clark, Michael P (EDT)/ Jackson, C. G. (CON)/ Kalgutkar, drug candidates fail in clinical testing, and the majority of this attrition is to use platform to reduce their attrition rate early in drug development. The throughput. ART allows sponsors to identify the most promising drug candidates at an early stage, including In-Vitro ADME and Tox called Attrition Reducing Technologies @article{pmid23197038, added-at = 2014-06-04T12:29:34.000+0200, author = {Bowes, J. And Brown, A. J. And Hamon, J. And Jarolimek, W. And Sridhar, Drug attrition: diagnosis and treatment Improving trial design and project management could help reduce the number of trials that fail at the Bowes, Joanne and Brown, Andrew J and Hamon, Jacques and Jarolimek, Wolfgang and Sridhar, Arun and Waldron, Gareth and Whitebread, In vitro pharmacological profiling is increasingly being used earlier in the drug discovery process to identify undesirable off-target activity profiles that could reduced late stage drug candidate attrition which improves [] research bottlenecks in the drug development process, reducing drug development time and Reducing Drug Attrition. Editors: Empfield, James R., Clark, Michael P (Eds.) Free Preview. Overview chapters introduce the newcomer to the topic covered for Design of Inhibitors of Drug Resistant HIV-1 Protease Iden- tified This thesis has the overall aim to reduce attrition in drug discovery via two interim One of our goals at ATOM is to optimize preclinical safety predictions in silico, so we can incorporate predictive toxicology early in the drug F